Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes
Elvan Üstün, Neslihan Şahin, Cem Çeli̇k, Uğur Tutar, Namık Özdemir, Nevın Gürbüz, İsmaıl Özdemır
Abstract
H} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules were examined in detail by molecular docking analysis. According to the results obtained, higher activity was achieved with the complex molecules when compared with the benzimidazole derivative ligands.
Topics & Concepts
AntimicrobialChemistryDocking (animal)Combinatorial chemistryStereochemistryOrganic chemistryMedicineNursingN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods