Interplay of Sphingolipid Metabolism in Predicting Prognosis of GBM Patients: Towards Precision Immunotherapy
Qi Wang, Chuanhua Zheng, Hanjin Hou, Xin Bao, Huading Tai, Xu‐Feng Huang, Zhengrui Li, Zhangzuo Li, Qiaowei Wang, Qi Pan, Longbin Wang, Shujing Zhou, Yanjie Bian, Qier Pan, Aihua Gong, Min Xu
Abstract
In summation, our exhaustive inquiry underscores the multifaceted utility of the sphingolipid metabolic pathway as an autonomous diagnostic and prognostic indicator for glioma patients. Furthermore, we amalgamate a profusion of substantiated evidence concerning immune infiltration and gene mutations, thereby reinforcing the proposition that sphingolipid metabolism may function as a pivotal determinant in the panorama of immunotherapeutic interventions.
Topics & Concepts
BiologySphingolipidComputational biologyImmunotherapyTranscriptomeImmune systemTumor microenvironmentSystems biologyGeneCancer researchBioinformaticsGeneticsGene expressionChronic Lymphocytic Leukemia ResearchPhagocytosis and Immune RegulationSphingolipid Metabolism and Signaling