Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models
Lei Wu, Yongjian Ai, Ruoxiao Xie, Jialiang Xiong, Yu Wang, Qionglin Liang
Abstract
. Organs-on-a-chip is also accelerating the process of faithfully mimicking the intestinal microenvironment. And by combining organoids and organ-on-a-chip technologies, they further are expected to serve as innovative preclinical tools and could outperform traditional cell culture models or animal models in the future. Above all, organoids/organs-on-a-chip with other strategies like genome editing, 3D printing, and organoid biobanks contribute to modeling intestinal homeostasis and disease. Here, the current challenges and future trends in intestinal pathophysiological models will be summarized.
Topics & Concepts
Organ-on-a-chipOrganoidPathophysiologyComputational biologyBiologyComputer scienceMedicineNeuroscienceNanotechnologyInternal medicineMicrofluidicsMaterials science3D Printing in Biomedical ResearchCancer Cells and MetastasisDiet and metabolism studies