Resolution of pretibial myxedema with teprotumumab in a patient with Graves disease

Abstract

Pretibial myxedema, also known as thyroid dermopathy, is a rare consequence of Graves disease and is occasionally observed in Hashimoto thyroiditis. It presents with various degrees of nonpitting edema, plaques, nodules, or elephantiasis.1 It typically develops after the onset of thyroid eye disease, with both conditions being linked to thyroid-stimulating hormone receptor antibodies causing activation and proliferation of fibroblasts.2 Effective treatment options for pretibial myxedema are limited.

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