The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway
Kaitlin M. Collura, Jingwen Niu, Shaun S. Sanders, Audrey Montersino, Sabrina Holland, Gareth M. Thomas
Abstract
shRNA knockdown reduced Gp130 palmitoylation and even more markedly reduced Gp130 surface expression, potentially explaining the importance of these PATs for Gp130-dependent signaling. Together, these findings provide new insights into the subcellular distribution and roles of specific PATs and reveal a novel mechanism by which palmitoylation controls axonal retrograde signaling.
Topics & Concepts
Glycoprotein 130AcyltransferasesChemistryCell biologySignal transductionSTAT3BiologyBiochemistryGeneBiosynthesisCytokine Signaling Pathways and InteractionsPharmacological Effects of Natural CompoundsNuclear Receptors and Signaling