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Aprocitentan, a dual endothelin-1 (ET-1) antagonist for treating resistant hypertension: Mechanism of action and therapeutic potential

Jing-Jing Xu, Xiaohua Jiang, Suowen Xu, Suowen Xu

2023Drug Discovery Today15 citationsDOI

Topics & Concepts

MedicineBlood pressureEndothelin receptorPharmacologyDihydropyridineThiazideAngiotensin IIEndothelin receptor antagonistMechanism of actionAntagonistAngiotensin-converting enzymeInternal medicineEndocrinologyReceptorCalciumChemistryIn vitroBiochemistryNitric Oxide and Endothelin EffectsBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies
Aprocitentan, a dual endothelin-1 (ET-1) antagonist for treating resistant hypertension: Mechanism of action and therapeutic potential | Litcius