A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy
Zhennan Zhao, Pan Gao, Li Ma, Tianfeng Chen
Abstract
prodrug is the highest among those reported for radiotherapy metal complex drugs. From detailed action mechanism study, we provide evidence that the prodrug is effectively suppresses the tumor growth through inducing mitochondrial dysfunction, and eventually amplifies the apoptotic signal pathway. This study provides an approach for the development of cancer theranostic agents for tumor radiotherapy.
Topics & Concepts
ProdrugIridiumRadiation therapyChemistryCancer researchMedicinePharmacologyInternal medicineCatalysisBiochemistryRadiopharmaceutical Chemistry and ApplicationsLanthanide and Transition Metal ComplexesMetal complexes synthesis and properties