3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate
Julien Nicolas, Sofia Magli, Linda Rabbachin, Susanna Sampaolesi, Francesco Nicotra, Laura Russo
Abstract
cell microenvironments. This requires fine-tuning the biochemical and structural actors in synthetic ECMs. This review will present the fundamentals of the ECM, cover the chemical and structural features of the scaffolds used to generate ECM mimics, discuss the nature of the signaling biomolecules required and exploited to generate bioresponsive cell microenvironments able to induce a specific cell fate, and highlight the synthetic strategies involved in creating functional 3D ECM mimics.
Topics & Concepts
Extracellular matrixRegenerative medicineChemistryBiomoleculeCell fate determinationChemical biologyDrug discoveryBiophysicsNanotechnologyCellIn vivoTissue engineeringCell biologyBiochemistryBiologyMaterials scienceBiotechnologyTranscription factorGeneGenetics3D Printing in Biomedical ResearchCellular Mechanics and InteractionsBone Tissue Engineering Materials