Self-assembled thioether-bridged paclitaxel-dihydroartemisinin prodrug for amplified antitumor efficacy-based cancer ferroptotic-chemotherapy
Yifei Zheng, Chao Qin, Fei Li, Jingxin Qi, Xinyu Chu, Hao Li, Ting Shi, Zhen Yan, Lei Yang, Xiaofei Xin, Lisha Liu, Xiaopeng Han, Lifang Yin
Abstract
In this study, ROS-sensitive prodrug nanoassemblies composed of a single thioether bond bridged dihydroartemisinin-paclitaxel prodrug was constructed. The nanoassemblies with enhanced ferroptotic-chemotherapy promoted tumor cell death.
Topics & Concepts
DihydroartemisininProdrugChemistryIntracellularPaclitaxelPharmacologyProgrammed cell deathCancer cellThioetherReactive oxygen speciesApoptosisCancer researchChemotherapyBiochemistryCancerBiologyArtemisininStereochemistryImmunologyPlasmodium falciparumGeneticsMalariaFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsMicroRNA in disease regulation