HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen‐West, Naeyma N. Islam, Thomas R. Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff‐Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong‐Jie Zhang, Leonard Petrucelli
Abstract
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Topics & Concepts
NeurologyPathologyMolecular medicineMedicineBiologyNeuroscienceBioinformaticsGeneticsGeneCell cycleAmyotrophic Lateral Sclerosis ResearchHereditary Neurological DisordersNeurogenetic and Muscular Disorders Research