Cobalt‐Catalyzed Cross‐Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides
Ferdinand H. Lutter, Lucie Grokenberger, Philipp Spieß, Jeffrey M. Hammann, Konstantin Karaghiosoff, Paul Knochel
Abstract
and 20 % 2,2'-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents with various (hetero)aryl halides. Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents proceeded diastereoselectively leading to functionalized heterocycles with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides react with primary and secondary alkylzinc reagents providing the alkylated alkynes.
Topics & Concepts
ArylCobaltHalideReagentCatalysisCombinatorial chemistryChemistryCoupling (piping)Materials scienceOrganic chemistryMetallurgyAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms