Further insight into the dual COX-2 and 15-LOX anti-inflammatory activity of 1,3,4-thiadiazole-thiazolidinone hybrids: The contribution of the substituents at 5th positions is size dependent
Yasser M. Omar, Samia G. Abdel‐Moty, Hajjaj H.M. Abdu-Allah
Topics & Concepts
PharmacophoreChemistryCelecoxibStereochemistryDocking (animal)Arachidonate 5-lipoxygenaseEnzymeActive siteIn vitroMolecular modelCombinatorial chemistryBiochemistryNursingArachidonic acidMedicineInflammatory mediators and NSAID effectsSynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation