Bacillus thuringiensis Cry1Ac Protoxin and Activated Toxin Exert Differential Toxicity Due to a Synergistic Interplay of Cadherin with ABCC Transporters in the Cotton Bollworm
Chong-Yu Liao, Minghui Jin, Ying Cheng, Yongbo Yang, Mário Soberón, Alejandra Bravo, Kaiyu Liu, Yutao Xiao
Abstract
Better understanding of the mode of action of Bacillus thuringiensis toxins is beneficial for the sustainable application of Bt crops. It is generally accepted that Cry-protoxins need to be activated by proteases to bind with midgut cell proteins and exert toxicity against insects.
Topics & Concepts
Cry1AcBacillus thuringiensisToxinBiologyHelicoverpa armigeraATP-binding cassette transporterMicrobiologyMutantReceptorBiochemistryTransporterBacteriaGeneGenetically modified cropsTransgeneGeneticsBotanyLepidoptera genitaliaInsect Resistance and GeneticsInsect and Pesticide ResearchGenetically Modified Organisms Research