Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)<sub>∞</sub> for oral drug delivery
Andrey A. Vodyashkin, Antonina V. Sergorodceva, Parfait Kezimana, Mariya Morozova, E. D. Nikolskaya, Mariia R. Mollaeva, N. G. Yabbarov, Maria Sokol, Margarita Chirkina, Leonid Butusov, А. А. Тимофеев
Abstract
). Similar results were observed in our apoptosis assays, as they revealed low apoptotic population generation of 2.52%, 3.23%, and 2.77% for Sr(BDC)(DMF), Sr(BDC) and Sr(BDC)(260 °C), respectively. Overall, the findings indicate that ethanol-activated Sr(BDC) shows potential as a safe and effective material for drug delivery.
Topics & Concepts
Metal-organic frameworkDrugChemistryDrug deliveryMetalInorganic chemistryNuclear chemistryPharmacologyOrganic chemistryMedicineAdsorptionMetal-Organic Frameworks: Synthesis and ApplicationsNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers