Binaphthyl-based chiral covalent organic frameworks for chiral drug separation
Hui‐Chao Ma, Haiping Jiang, Zi-Hui Yao, Junfeng Tan, Yang‐Yang Xing, Gong-Jun Chen, Yu‐Bin Dong
Abstract
= 3.39) factors. Meanwhile, the separation of six racemic drugs by the (R)-BHTP-COF-packed column exhibited high resolution, selectivity, and durability. The successful applications indicate the great potential of CCOFs as a novel stationary phase for efficient HPLC separation.
Topics & Concepts
Covalent bondChemistryDrugCombinatorial chemistrySeparation (statistics)StereochemistryOrganic chemistryPharmacologyComputer scienceMedicineMachine learningCovalent Organic Framework ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsLuminescence and Fluorescent Materials