Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management
Rui Wang, Yanfang Sun, Han Wang, Tianqi Liu, Amin Shavandi, Lei Nie, Khaydar E. Yunusov, Guohua Jiang
Abstract
results showed that the as-fabricated MNs exhibited an excellent anti-hyperuricemia effect to reduce SUA levels to the normal state within 3 h and maintain the normouricemia state for 12 h. In addition, the levels of creatinine (Cr) and blood urea nitrogen (BUN) in the serum remained within the normal range, and the activities of adenosine deaminase (ADA) and xanthine oxidase (XOD) in the liver were effectively inhabited, mitigating the risk of liver and kidney damage for clinical anti-hyperuricemia management.
Topics & Concepts
Uric acidHyperuricemiaUrate oxidasePharmacologyXanthine oxidaseChemistryHypoxanthineGoutAllantoinMaterials scienceBiochemistryMedicineEnzymeGout, Hyperuricemia, Uric AcidDermatology and Skin DiseasesAdvancements in Transdermal Drug Delivery