Human circulating small non-coding RNA signature as a non-invasive biomarker in clinical diagnosis of acute myeloid leukaemia
Xia Lin, Huanping Guo, Xiao Wu, Yinying Xu, Pan Zhao, Bingbing Yan, Yunjing Zeng, Yundi He, Dan Chen, Robert Peter Gale, Yunfang Zhang, Xi Zhang
Abstract
We comprehensively characterized the expression pattern of circulating sncRNAs in blood and bone marrow and their alteration signature between healthy controls and AML patients. This study enriches research of sncRNAs in the regulation of AML, and provides insights into the role of sncRNAs in AML.
Topics & Concepts
microRNABone marrowBiomarkerBiologyTranscriptomeMyeloidImmunologyComputational biologyGeneGene expressionGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerMicroRNA in disease regulation