Mast Cell-Derived Proteases Induce Endothelial Permeability and Vascular Damage in Severe Fever with Thrombocytopenia Syndrome
Yuna Wang, Yun-Fa Zhang, Xue‐Fang Peng, Hong‐Han Ge, Gang Wang, Heng Ding, Yue Li, Shuang Li, Lingyu Zhang, Jingtao Zhang, Hao Li, Xiao‐Ai Zhang, Wei Liu
Abstract
We revealed a pathogenic role for MCs in response to SFTSV infection. The study also identifies potential biomarkers that could differentiate patients at risk of a fatal outcome for SFTS, as well as novel therapeutic targets for the clinical management of SFTS. These findings might shed light on an emerging role for MCs as a potential drug target during infection of other viral hemorrhagic fever diseases with similar host pathology as SFTS.
Topics & Concepts
ProteasesMast cellVascular permeabilityImmunologyEndothelial stem cellPermeability (electromagnetism)MedicinePathologyBiologyEnzymeGeneticsBiochemistryMembraneIn vitroViral Infections and VectorsMosquito-borne diseases and controlImmune Cell Function and Interaction