Blocking MARCO+ tumor-associated macrophages improves anti-PD-L1 therapy of hepatocellular carcinoma by promoting the activation of STING-IFN type I pathway
Limin Ding, Junjie Qian, Xizhi Yu, Qinchuan Wu, Jing Mao, Xi Liu, Yubo Wang, Danjing Guo, Rong Su, Haiyang Xie, Shengyong Yin, Lin Zhou, Shusen Zheng
Topics & Concepts
Tumor microenvironmentImmunotherapyCancer researchCancer immunotherapyImmune systemCD8CancerTumor-associated macrophagePD-L1Liver cancerHepatocellular carcinomaT cellMonoclonal antibodyMedicineMacrophageImmunologyAntibodyBiologyIn vitroInternal medicineBiochemistryImmune cells in cancerImmune Cell Function and Interactioninterferon and immune responses