Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions
John Onyebuchi Ogbodo, Chinazom Precious Agbo, Ugochi Olivia Njoku, Martins Obinna Ogugofor, Simeon Ikechukwu Egba, Stella Amarachi Ihim, Adaeze Chidiebere Echezona, Kenneth C. Brendan, Aman B. Upaganlawar, Chandrashekhar Upasani
Abstract
BACKGROUND: Alzheimer's Disease (AD) is the most common cause of dementia. Genetics, excessive exposure to environmental pollutants, as well as unhealthy lifestyle practices are often linked to the development of AD. No therapeutic approach has achieved complete success in treating AD; however, early detection and management with appropriate drugs are key to improving prognosis. INTERVENTIONS: The pathogenesis of AD was extensively discussed in order to understand the reasons for the interventions suggested. The interventions reviewed include the use of different therapeutic agents and approaches, gene therapy, adherence to healthy dietary plans (Mediterranean diet, Okinawan diet and MIND diet), as well as the use of medicinal plants. The potential of nanotechnology as a multidisciplinary and interdisciplinary approach in the design of nano-formulations of AD drugs and the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic tools for early detection of Alzheimer's disease were also discussed.