In Sickness and in Health: The Oxygen Reactive Species and the Bone
Joana Reis, António Ramos
Abstract
Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.
Topics & Concepts
Oxidative stressPathologicalReactive oxygen speciesBone healthPerspective (graphical)Balance (ability)PopulationMedicineIntensive care medicineNeuroscienceBiologyPathologyCell biologyOsteoporosisEnvironmental healthInternal medicineArtificial intelligenceComputer scienceBone mineralBone Metabolism and DiseasesCancer, Hypoxia, and MetabolismAlkaline Phosphatase Research Studies