Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Alexander Bujotzek, Georg Tiefenthaler, Laurent Larivière, Laura D’Andrea, Elsa A. Marquez, Ina Rudloff, Steven Cho, Nadia S. Deen, W. Richter, Franziska Regenass-Lechner, Alexander Poehler, James C. Whisstock, Jasmin Sydow-Andersen, Xaver Reiser, Sabine Schuster, Jeannette Neubauer, Sebastian Hoepfl, Kirsten Richter, Marcel F. Nold, Claudia A. Nold‐Petry, Felix Schumacher, Andrew M. Ellisdon
Topics & Concepts
Fusion proteinCytokineTumor necrosis factor alphaProtein engineeringImmune systemInnate immune systemImmunologyMutagenesisMedicineBiologyMutationEnzymeRecombinant DNABiochemistryGeneToxin Mechanisms and ImmunotoxinsTransgenic Plants and ApplicationsMonoclonal and Polyclonal Antibodies Research