Ru(II)-Catalyzed Amination of Aryl Fluorides <i>via</i> η<sup>6</sup>-Coordination
Qi‐Kai Kang, Yunzhi Lin, Yuntong Li, Hang Shi
Abstract
We developed a Ru/hemilabile-ligand-catalyzed nucleophilic aromatic substitution (SNAr) of aryl fluorides as the limiting reagents. Significant ligand enhancement was demonstrated by the engagement of both electron-rich and neutral arenes in the SNAr amination without using excess arenes. Preliminary mechanistic studies revealed that the nucleophilic substitution proceeds on a η6-complex of the Ru catalyst and the substrate, and the hemilabile ligand facilitates dissociation of products from the metal center.
Topics & Concepts
ChemistryNucleophilic aromatic substitutionAminationArylCatalysisLigand (biochemistry)NucleophileReagentMedicinal chemistryHydroaminationSubstitution reactionDissociation (chemistry)Nucleophilic substitutionCombinatorial chemistryOrganic chemistryReceptorAlkylBiochemistryCatalytic Cross-Coupling ReactionsFluorine in Organic ChemistryCatalytic C–H Functionalization Methods