Rapid Quantification of Pharmaceuticals via <sup>1</sup>H Solid-State NMR Spectroscopy
Y. T. Angel Wong, Ruud L. E. G. Aspers, Marketta Uusi-Penttilä, Arno P. M. Kentgens
Abstract
H spectral resolution with standard equipment, and data analysis can be accomplished with ease, even for structurally complex APIs. Using several API species as model systems, we show that CRAMPS-MAR can provide a lower quantitation limit than standard approaches such as fast MAS with peak integration. Furthermore, CRAMPS-MAR was found to be robust for cases that are inapproachable by conventional ultra-fast (i.e., 100 kHz) MAS methods even when state-of-the-art SSNMR equipment was employed. Our results demonstrate CRAMPS-MAR as an alternative quantification technique that can generate new opportunities for analytical research.
Topics & Concepts
ChemistrySpectroscopyCharacterization (materials science)Solid-state nuclear magnetic resonanceResolution (logic)Nuclear magnetic resonance spectroscopySolid-stateDetection limitAnalytical Chemistry (journal)NanotechnologyChromatographyNuclear magnetic resonanceOrganic chemistryPhysical chemistryMaterials scienceComputer scienceArtificial intelligencePhysicsQuantum mechanicsAdvanced NMR Techniques and ApplicationsNMR spectroscopy and applicationsMolecular spectroscopy and chirality