Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFRT790M mutant cell lines
Lei Zhao, Tingting Fan, Zhichao Shi, Chao Ding, Cunlong Zhang, Zigao Yuan, Qinsheng Sun, Chunyan Tan, Bizhu Chu, Yuyang Jiang
Topics & Concepts
T790MChemistryCell cultureEGFR inhibitorsCancer researchHydroxamic acidProtein kinase BMutantCell growthErbBGefitinibPhosphorylationEpidermal growth factor receptorSignal transductionBiochemistryBiologyReceptorGeneStereochemistryGeneticsLung Cancer Treatments and MutationsCancer therapeutics and mechanismsHistone Deacetylase Inhibitors Research