Transformer-Based High-Frequency Oscillation Signal Detection on Magnetoencephalography From Epileptic Patients
Jiayang Guo, Naian Xiao, Hailong Li, Lili He, Qiyuan Li, Ting Wu, Xiaonan He, Peizhi Chen, Duo Chen, Jing Xiang, Xueping Peng
Abstract
High-frequency oscillations (HFOs), observed within 80–500 Hz of magnetoencephalography (MEG) data, are putative biomarkers to localize epileptogenic zones that are critical for the success of surgical epilepsy treatment. It is crucial to accurately detect HFOs for improving the surgical outcome of patients with epilepsy. However, in clinical practices, detecting HFOs in MEG signals mainly depends on visual inspection by clinicians, which is very time-consuming, labor-intensive, subjective, and error-prone. To accurately and automatically detect HFOs, machine learning approaches have been developed and have demonstrated the promising results of automated HFO detection. More recently, the transformer-based model has attracted wide attention and achieved state-of-the-art performance on many machine learning tasks. In this paper, we are investigating the suitability of transformer-based models on the detection of HFOs. Specifically, we propose a transformer-based HFO detection framework for biomedical MEG one-dimensional signal data. For signal classification, we develop a transformer-based HFO (TransHFO) classification model. Then, we investigate the relationship between depth of deep learning models and classification performance. The experimental results show that the proposed framework outperforms the state-of-the-art HFO classifiers, increasing classification accuracy by 7%. Furthermore, we find that shallow TransHFO ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m1"><mml:mo><</mml:mo></mml:math> 10 layers) outperforms deep TransHFO models (≥10 layers) on most data augmented factors.