<i>O</i> -GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5
Qiming Wang, Peining Fang, Rui He, Mengqi Li, Haisheng Yu, Li Zhou, Yi Yu, Fubing Wang, Yuan Rong, Yi Zhang, Aidong Chen, Nanfang Peng, Yong Lin, Mengji Lu, Ying Zhu, Guoping Peng, Liqun Rao, Shi Liu
Abstract
-GlcNAcylation regulates IRF5 function during IAV infection, highlighting the importance of glucose metabolism in IAV-induced cytokine storm.
Topics & Concepts
InterferonCytokine stormVirusCytokineInfluenza A virusInterferon regulatory factorsVirologyBiologyCell biologyImmunologyChemistryMedicineCoronavirus disease 2019 (COVID-19)Immune systemInnate immune systemInfectious disease (medical specialty)PathologyDiseaseGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyImmune Cell Function and Interaction