The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice
Xueyang Li, Cong He, Nianshuang Li, Ling Ding, Hongyan Chen, Jianhua Wan, Xiaoyu Yang, Liang Xia, Wenhua He, Huifang Xiong, Xu Shu, Yin Zhu, Nonghua Lü
Abstract
was observed in WT mice suffering from AP, there was no significant change in NLRP3 KO mice with or without AP, suggesting that NLRP3 deficiency counteracts AP-induced microbial disturbance. With a strengthened gut barrier and decreased systemic inflammation, NLRP3 KO mice showed less severe AP, as revealed by reduced pancreatic neutrophilic infiltration and necrosis. Taken together, these results identified the bidirectional modulation between the gut microbiota and NLRP3 in the progression of AP, which suggests the interplay of the host and microbiome during AP.
Topics & Concepts
BiologyGut floraAcute pancreatitisPancreatitisImmunologyInternal medicineMedicinePancreatitis Pathology and TreatmentGut microbiota and healthLiver Disease Diagnosis and Treatment