KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
Pranavi Koppula, Kellen Olszewski, Yilei Zhang, Lavanya Kondiparthi, Xiaoguang Liu, Guang Lei, Molina Das, Bingliang Fang, Masha V. Poyurovsky, Boyi Gan
Abstract
deficiency induces glucose dependency in lung cancer cells and uncover a therapeutically relevant metabolic liability.
Topics & Concepts
Lung cancerCancer researchCancer cellGlucose transporterCancerChemistryKEAP1Cell biologyBiologyBiochemistryMedicineEndocrinologyInternal medicineTranscription factorGeneInsulinGenomics, phytochemicals, and oxidative stressMicroRNA in disease regulationRNA modifications and cancer