HIV-1 infection of the kidney: mechanisms and implications
Kelly Hughes, Jerry Chang, Hannah Stadtler, Christina Wyatt, Mary Klotman, Maria Blasi
Abstract
People living with HIV are at higher risk for acute and chronic kidney disease compared with uninfected individuals. Kidney disease in this population is multifactorial, with several contributors including HIV infection of kidney cells, chronic inflammation, genetic predisposition, aging, comorbidities, and coinfections. In this review, we provide a summary of recent advancements in the understanding of the mechanisms and implications of HIV infection and kidney disease, with particular focus on the role of direct HIV infection of renal cells.
Topics & Concepts
Kidney diseaseMedicineImmunologyHuman immunodeficiency virus (HIV)PopulationKidneyDiseaseImmunopathologyViral diseaseIntensive care medicineChronic infectionVirologyLentivirusBiologyVirusBioinformaticsSidaHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV-related health complications and treatments