Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle
Kohei Kido, Tatsuro Egawa, Shinya Watanabe, Kentaro Kawanaka, Jonas T. Treebak, Tatsuya Hayashi
Abstract
In this study, we revealed that 36 h of fasting additively upregulated acute muscle contraction-induced AMPK pathway activation in rats. Besides, fasting and muscle contraction synergistically enhanced insulin-stimulated site-specific TBC1D4 phosphorylation and glucose uptake, which was associated with augmented AMPK pathway activation. These results contribute to understanding the regulation of muscle insulin sensitivity.
Topics & Concepts
Internal medicineEndocrinologyAMPKInsulinContraction (grammar)Skeletal muscleDownregulation and upregulationProtein kinase BMedicineMuscle contractionGlucose uptakePhosphorylationChemistryProtein kinase ABiochemistryGeneMetabolism, Diabetes, and CancerPancreatic function and diabetesAdipose Tissue and Metabolism