Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells
Agata Wawrzkiewicz–Jałowiecka, Anna Lalik, Agnieszka Łukasiak, M. Richter, Paulina Trybek, Maciej Ejfler, Maciej Opałka, Sonia Wardejn, Domenico Vittorio Delfino
Abstract
Potassium channels emerge as one of the crucial groups of proteins that shape the biology of cancer cells. Their involvement in processes like cell growth, migration, or electric signaling, seems obvious. However, the relationship between the function of K+ channels, glucose metabolism, and cancer glycome appears much more intriguing. Among the typical hallmarks of cancer, one can mention the switch to aerobic glycolysis as the most favorable mechanism for glucose metabolism and glycome alterations. This review outlines the interconnections between the expression and activity of potassium channels, carbohydrate metabolism, and altered glycosylation in cancer cells, which have not been broadly discussed in the literature hitherto. Moreover, we propose the potential mediators for the described relations (e.g., enzymes, microRNAs) and the novel promising directions (e.g., glycans-orinented drugs) for further research.