SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection
Xiaolin Zhang, Ziwei Yang, Ting Pan, Xubing Long, Qinqin Sun, Pei‐Hui Wang, Xiaojuan Li, Ersheng Kuang
Abstract
CQ: chloroquine; DEGs: differentially expressed genes; ER: endoplasmic reticulum; GSEA: gene set enrichment analysis; HMGB1: high mobility group box 1; HMOX1: heme oxygenase 1; MERS-CoV: Middle East respiratory syndrome coronavirus; RETREG1/FAM134B: reticulophagy regulator 1; RTN4: reticulon 4; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TN: tunicamycin.
Topics & Concepts
AutophagyBiologyBECN1Immune systemPathogenesisInflammationImmunologyUnfolded protein responseULK1ApoptosisCell biologyGeneticsAMPKProtein kinase APhosphorylationAutophagy in Disease and TherapyPhagocytosis and Immune RegulationEndoplasmic Reticulum Stress and Disease