Advances on the Synthesis of N—N Bonds
Weizhe Zhao, Jiali Xu, Fan Yang, Xianghua Zeng
Abstract
Nitrogen-nitrogen bonds are widely found in drugs, nature products and organic materials. Design and synthesis of nitrogen-nitrogen motifs with high efficiency have always been an important issue in organic chemistry. The nitrogen sources such as amines, nitriles, nitroso, and azides or other N-functionalized reagents, are commonly exist in organic compounds. Direct N-N coupling of these nitrogen sources provides a more convergent synthesis strategy to produce different heterocycles and hydrazines containing the N-N motif. In this paper, the intermolecular and intramolecular formation of N-N bond in recent years is reviewed, and the difficulties and future development of this method are prospected.