Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers
Niranjan Meher, Gary W. Ashley, Anil P. Bidkar, Suchi Dhrona, Cyril O.Y. Fong, Shaun D. Fontaine, Denis Beckford-Vera, David M. Wilson, Youngho Seo, Daniel V. Santi, Henry F. VanBrocklin, Robert R. Flavell
Abstract
showed low EPR-mediated accumulation with poor tumor tissue penetration. Overall, ACUPA conjugated targeted starPEGs significantly improve tumor retention with deep tumor tissue penetration in low EPR PC3-Pip xenografts. These data suggest that PSMA targeting with multivalent ACUPA ligands may be a generally applicable strategy to increase nanocarrier delivery to prostate cancer. These targeted multivalent nanocarriers with high tumor binding and low healthy tissue retention could be employed in imaging and therapeutic applications.
Topics & Concepts
NanocarriersIn vivoCancer researchMaterials scienceIn vitroBiophysicsDrug deliveryChemistryNanotechnologyMedicineBiochemistryBiologyBiotechnologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery