Recent Advances in the Use of 2‐Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N‐Heterocycles
Fatemeh Doraghi, Farzad Gilaninezhad, Somaye Karimian, Amir Mohammad Mahdavian, Bagher Larijani, Mohammad Mahdavi
Abstract
Abstract N‐Heterocyclic compounds, in particular, quinolines and quinazolines are frequently used in medicinal chemistry. Therefore, the direct and clean synthesis of these valuable scaffolds has been a great interest for many years. 2‐Aminobenzyl alcohols as an alternative reactant instead of unstable and expensive 2‐aminobenzaldehydes can be used in the construction of N‐fused heterocycles including quinolines, quinazolines, oxazines, thiazines, selenazines, imidazoles, diazepines, etc. In this review article, we have discussed recent developments in the use of 2‐aminobenzyl alcohols in the synthesis of diverse heterocycles.
Topics & Concepts
ChemistryCombinatorial chemistryOrganic chemistryQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsPhenothiazines and Benzothiazines Synthesis and Activities