Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E <sub>2</sub> receptor EP2 subtype
Changxiu Qu, Chunyou Mao, Peng Xiao, Qingya Shen, Ya-Ni Zhong, Fan Yang, Dandan Shen, Xiao-Na Tao, Huibing Zhang, Yan Xu, Ru-Jia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, Pengju Zhang, Gui‐Ge Hou, Zijian Li, Xiao Yu, Renjie Chai, Youfei Guan, Jin‐Peng Sun, Yan Zhang
Abstract
Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism.
Topics & Concepts
Prostaglandin E2 receptorReceptorLigand (biochemistry)ChemistryProstaglandin E2G protein-coupled receptorCell biologyNeuroscienceBiologyBiochemistryEndocrinologyAgonistReceptor Mechanisms and SignalingInflammatory mediators and NSAID effectsNitric Oxide and Endothelin Effects