PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes
Chang‐Keun Cho, Eunvin Ko, Ju Yeon Mo, Pureum Kang, Choon‐Gon Jang, Seok‐Yong Lee, Yun Jeong Lee, Jung‐Woo Bae, Chang‐Ik Choi
Topics & Concepts
PantoprazoleCYP2C19PharmacokineticsPhysiologically based pharmacokinetic modellingPharmacologyCmaxOmeprazolePharmacodynamicsChemistryGERDCYP3A4MedicineInternal medicineCytochrome P450RefluxDiseaseMetabolismHelicobacter pylori-related gastroenterology studiesGastroesophageal reflux and treatmentsPharmacogenetics and Drug Metabolism