Antibiotic Acyldepsipeptides Stimulate the <i>Streptomyces</i> Clp-ATPase/ClpP Complex for Accelerated Proteolysis
Laura Reinhardt, Dhana Thomy, Markus Lakemeyer, Linda M. Westermann, Joaquı́n Ortega, Stephan A. Sieber, Peter Saß, Heike Brötz‐Oesterhelt
Abstract
Clp proteases are antibiotic and anticancer drug targets. Composed of the proteolytic core ClpP and a regulatory Clp-ATPase, the protease machinery is important for protein homeostasis and regulatory proteolysis.
Topics & Concepts
ProteolysisProteaseProteasesAAA proteinsStreptomycesBiochemistryATPaseBiologyMicrobiologyEnzymeProtein degradationChemistryBacteriaGeneticsRNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesMicrobial Natural Products and Biosynthesis