Research Progress on the Pharmacological Action of Schisantherin A
Zehao Xiao, Wen Xiao, Guilin Li
Abstract
Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A.
Topics & Concepts
Schisandra chinensisProtein kinase BPI3K/AKT/mTOR pathwayMAPK/ERK pathwayPharmacologyChemistryMechanism of actionLignanApoptosisSchisandraTraditional medicineMedicineSignal transductionBiochemistryTraditional Chinese medicineStereochemistryIn vitroAlternative medicinePathologyPlant-derived Lignans Synthesis and BioactivityGenomics, phytochemicals, and oxidative stressPeroxisome Proliferator-Activated Receptors