Infection with SARS-CoV-2 as potential achalasia trigger
Pilar Ruz Zafra, Carlos Javier García-Sánchez, Alberto Pérez Ramírez, Ana Guil Soto, Eduardo Leo Carnerero
Abstract
Idiopathic achalasia is a chronic oesophageal motility disorder caused by loss of inhibitory neurons at the esophageal myenteric plexus resulting in incomplete relaxation of the lower oesophageal sphincter and abnormal peristaltism. Among the possible causes of this, an immune response secondary to infection by some viruses has been implicated. SARS-CoV-2 could be considered among them. The therapy option should be aimed at achieving the greatest clinical effectiveness according to each patient's health status.
Topics & Concepts
AchalasiaMedicineMyenteric plexusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Esophageal sphincterGastroenterologyCoronavirus disease 2019 (COVID-19)Esophageal motility disorderMotilityHigh resolution manometryInternal medicineEsophagusDiseaseRefluxImmunohistochemistryInfectious disease (medical specialty)BiologyGeneticsGastroesophageal reflux and treatmentsDysphagia Assessment and ManagementEosinophilic Esophagitis