Diastereoselective Synthesis of β-Lactams by Ligand-Controlled Stereodivergent Intramolecular Tsuji–Trost Allylation
Matteo Faltracco, Verena Sukowski, Max van Druenen, Trevor A. Hamlin, F. Matthias Bickelhaupt, Eelco Ruijter
Abstract
isomer (with yields and diastereoselectivity ranging from modest to excellent depending on the substrate). The reaction proceeds under exceedingly mild conditions (rt, no additives) with a broad range of substrates, which are readily accessible by the Ugi reaction.
Topics & Concepts
Intramolecular forceLigand (biochemistry)StereochemistryChemistryReceptorBiochemistrySynthesis and Catalytic ReactionsSynthesis of β-Lactam CompoundsSynthetic Organic Chemistry Methods