Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function
Chethan Sampath, Abhinav V. Raju, Michael L. Freeman, Shanthi Srinivasan, Pandu R. Gangula
2022American Journal of Physiology-Gastrointestinal and Liver Physiology18 citationsDOIOpen Access PDF
Abstract
Primary neuronal cell crust (pENCs) in the intestine habitats nNOS and Nrf2, which was suppressed in diabetic gastroparesis. Activation of Nrf2 restored nNOS by suppressing inflammatory markers in pENCs cells. Inhibition of Nrf2 reveals a negative feedback mechanism for the activation of GSK-3. Activation of Nrf2 alleviates STZ-induced delayed gastric emptying and nitrergic relaxation in female mice. Activation of Nrf2 restored impaired gastric BH 4 biosynthesis enzyme GCH-1, nNOSα expression thus regulating nitric oxide levels.
Topics & Concepts
EndocrinologyNitric oxideInternal medicineInterstitial cell of CajalStomachGastroparesisChemistryGastric emptyingBiologyMedicineSmooth muscleHelicobacter pylori-related gastroenterology studiesGastrointestinal motility and disordersCongenital gastrointestinal and neural anomalies