Rutin-loaded polymeric nanorods alleviate nephrolithiasis by inhibiting inflammation and oxidative stress <i>in vivo</i> and <i>in vitro</i>
Sarmistha Saha, Abhijit Mishra
Abstract
). Rutin nanorods resulted in significant protection in serum and urinary biochemistry with reduced calcifications and increased tissue viability of kidneys without any toxicity and achieved high bioavailability. Our data provide a facile strategy for the use of rutin nanorods as a targeted drug system to treat and prevent renal stone formations.
Topics & Concepts
RutinNanorodChemistryOxidative stressBioavailabilityIn vivoAntioxidantMaterials sciencePharmacologyBiochemistryNanotechnologyMedicineBiotechnologyBiologyKidney Stones and Urolithiasis TreatmentsBiomedical Research and PathophysiologyTherapeutic Uses of Natural Elements