Regiodivergent Radical-Relay Alkene Dicarbofunctionalization
Zhong Liu, Francesco D’Amico, Rubén Martı́n
Abstract
Herein, we report a regiodivergent 1,n-dicarbofunctionalization of unactivated olefins enabled by a Ni-catalyzed radical relay that forges both C( sp 3 )-C( sp 3 ) and C( sp 2 )–C( sp 3 ) linkages, even at long-range. Initial studies support an intertwined scenario resulting from the merger of an atom-transfer radical addition (ATRA) and a chain-walking event, with site-selectivity being dictated by a judicious choice of the ligand backbone.
Topics & Concepts
ChemistryAlkeneRelayRadical ionStereochemistryCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryIonQuantum mechanicsPhysicsPower (physics)Catalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions