Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy E. Murphy, Angus D. Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli
Topics & Concepts
BromodomainCooperativityUbiquitin ligaseChemistryTernary complexUbiquitinLinkerPlasma protein bindingAllosteric regulationBiochemistryBivalent (engine)AvidityCooperative bindingProteolysisCell biologyBiophysicsBinding siteStereochemistryBiologyDNAReceptorGeneticsAntigenGeneMetalOperating systemEnzymeHistoneComputer scienceOrganic chemistryProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways