OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1
Akhee Sabiha Jahan, Élise Biquand, Raquel Muñoz-Moreno, Agathe Le Quang, Chris Mok, Ho Him Wong, Qi Wen Teo, Sophie A. Valkenburg, Alex W. H. Chin, Leo L. M. Poon, Artejan te Velthuis, Adolfo García‐Sastre, Caroline Demeret, Sumana Sanyal
Abstract
S]IRF3, purified RIG-I, mitochondrial membranes, and cytosol expressing OTUB1 variants. A range of IAV NS1 proteins trigger proteasomal degradation of OTUB1, antagonizing the RIG-I signaling cascade and antiviral responses.
Topics & Concepts
RIG-ICell biologyIRF3UbiquitinBiologyRegulatorSignal transductionDeubiquitinating enzymeImmune systemInnate immune systemBiochemistryImmunologyGeneinterferon and immune responsesUbiquitin and proteasome pathwaysImmune Response and Inflammation