Construction of Cyclophane-Braced Peptide Macrocycles via Palladium-Catalyzed Picolinamide-Directed Intramolecular C(sp<sup>2</sup>)–H Arylation
Boyang Han, Bo Li, Liping Qi, Peng Yang, Gang He, Gong Chen
Abstract
)-linked cyclophane peptide macrocycles via Pd-catalyzed picolinamide-directed intramolecular arylation of aryl and alkenyl C-H bonds of amino acid side chains with aryl iodides is developed. This method provides simple and efficient access to a variety of cyclophane-braced structures from readily accessible linear peptide precursors.
Topics & Concepts
ChemistryIntramolecular forcePalladiumCyclophaneCatalysisStereochemistryPeptideCombinatorial chemistryMoleculeMedicinal chemistryOrganic chemistryBiochemistryCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions