The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma
Zhijian Kuang, Kaiqiang Guo, Yin Cao, Mengxue Jiang, Chaojie Wang, Qiaoqiong Wu, Guo-Sheng Hu, Mingtao Ao, Mingfeng Huang, Jingbo Qin, Taige Zhao, Sheng Lu, Cuiling Sun, Mingyu Li, Tong Wu, Wen Liu, Meijuan Fang
Topics & Concepts
Clear cell renal cell carcinomaCancer researchGene knockdownCyclin-dependent kinase 9BRD4KinomeBiologyCell cycleKinaseChemistryCellCell cultureMedicineCyclin-dependent kinase 2Renal cell carcinomaBromodomainCell biologyPathologyBiochemistryEpigeneticsGeneticsGeneProtein Degradation and InhibitorsMicrotubule and mitosis dynamicsRenal cell carcinoma treatment