Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma
Xiao Zhang, Keke Yu, Lifang Ma, Zijun Qian, Xiaoting Tian, Yayou Miao, Yongjie Niu, Xin Xu, Susu Guo, Yueyue Yang, Zhixian Wang, Xiangfei Xue, Chuanjia Gu, Wentao Fang, Jiayuan Sun, Yongchun Yu, Jiayi Wang
Abstract
in LUAD cells, and ferroptosis-based treatment is a good choice for LUAD patients with later-stage and/or therapy-resistant tumors.
Topics & Concepts
EndogenySensitivity (control systems)Glutamate receptorLungAdenocarcinomaChemistryCancer researchCell biologyBiologyMedicineInternal medicineBiochemistryCancerReceptorEngineeringElectronic engineeringCancer-related molecular mechanisms researchFerroptosis and cancer prognosisRNA modifications and cancer